Competitive advantages over undenatured (unhydrolyzed) collagen

 BioCell Collagen® (Hydrolyzed)Undenatured
Collagen type 1type II (hydrolyzed)type II (unhydrolyzed)
Hyaluronic acid and chondroitin sulfate 2yes?
Molecular weight of collagen 41.5 - 2.5 kDa200 - 300 kDa
Efficient absorption 5yes?
Clinical HA bioavailabilityabout 60-fold increase?
Chondrocyte stimulation 6yesno
Inhibition of hyaluronidase 7yes?
Targeted tissuesjoint and skinjoint
Efficacy in human studiesjoint and skinjoint
  1. Type II collagen is a predominant type of collagen in articular cartilage.
    Hydrolyzed form is also effective in reducing UV damage in the skin (Tanaka et al, 2009, Biotechnol Biochem)
  2. Essential components both for the joint and the skin. Chondroitin suflate has anti-inflammatory activity.
  3. Average molecular weight. Patented hydolysis for BioCell Collagen®.
  4. Oesser et al, 1999, J Nutr, 129:1891-1895.
  5. Oesser et al, 2003, Cell Tissue Res, 311:393-399. Only hydrolyzed collagen stimulates type II collagen biosynthesis.
  6. Hyaluronidase-specific.

BioCell Collagen advantages over native/undenatured/unhydrolyzed collagen

  1. BioCell Collagen provides a comprehensive support for the cartilage with collagen type II, HA, and chondroitin sulfate, all of which are essential for the cartilage.
    Native/undenatured/unhydrolyzed collagen may provide collagen type II only, giving a partial solution without substantial GAG support.
  2. BioCell Collagen supports the synovial joint with HA which is a major lubricating agent.
  3. The bioavailability of BioCell Collagen is proven in humans.
  4. Hydrolyzed collagen type II contained in BioCell Collagen stimulated the cartilage-making chondrocytes whereas undenatured collagen failed to do so.
  5. BioCell Collagen demonstrated its safety and efficacy in promoting both joint and skin health through multiple human clinical trials.

Competitive advantages over other hydrolyzed collagen

 BioCell Collagen®Other Hydrolyzed Collagen
Collagen type 1type IItype I
GAGs (HA, chondroitin sulfate) 2yes?
Daily dose of clinical efficacy1g (skin), 2g (joint)10g
Hydrolysis for higher bioavailabilityyesyes

Average Molecular Weight

 

1.5 kDa

yes

3.5 kDa

?

Chondrocyte stimulation for collagen synthesisyesyes
Inhibition of hyaluronidaseyes?
Efficacy in human studiesjoint and skinjoint and skin
  1. Major type of collagen in the final products. Type II is the predominant type of articular cartilage.
  2. Essential components both for joint and skin. HA for hydration and chondroitin sulfate for resistance and cushion.
  3. Average molecular weight. Patented hydrolysis for BioCell Collagen ®
  4. HA bioavailability study in human subjects, Judy, W, SIBR research.

BioCell Collagen advantages over other hydrolyzed collagen

  1. Type II is specific for the articular cartilage
  2. BioCell Collagen, unlike other hydrolyzed collagen products, also contains bioavailable GAGs such as HA and chondroitin sulfate, providing a holistic support for joint and skin.
  3. Much smaller sizes potentially for better absorption
  4. Lower daily dose
  5. Inhibition of HA-degrading hyaluronidase, providing another layer of HA support.

Competitive advantages over eggshell or fish-derived collagen

 BioCell Collagen® (hydrolyzed)Eggshell Membrane
Primary collagen typetype IItype I
Hydrolyzed collagen for bioavailabilityyes?
Content / collagen
chondoitin sulfate
hyaluronic acid		>60%
>20%
>10%		12 ~ 18%
0.2 ~ 0.5%
0.5 ~ 1.0%
Efficient absorptionyes?
Clinical HA bioavailabilityabout 60-fold increase?
Chondrocyte stimulationyes?
Inhibition of hyaluronidaseyes?
Studies of joint discomfort
Pain /stiffness
Joint functions
Total score
yes
yes
yes
yes
no
no

 

BioCell Collagen advantages over collagen sourced from eggshell membrane or fish skin

  1. Type II collagen is a predominant type of collagen in the human articular cartilage. The collagen content of eggshell membrane is much smaller than BioCell Collagen and its collagen is type I.
  2. GAGs such as HA and chondroitin sulfate are essential for joint health and the skin beauty. Their content in eggshell membrane or in fish skin/scales is much lower than in BioCell Collagen.
  3. BioCell Collagen offers a comprehensive support for joint health and skin beauty via multiple mechanisms of action.
  4. A clinical trial on eggshell membrane collagen showed its limited effect in managing joint discomfort. BioCell Collagen demonstrated a full-range of clinical efficacy.